Postdoctoral training positions are available in the laboratory of Dr. Chun-Li Zhang, Professor, Department of Molecular Biology, Center for Regenerative Science and Medicine at UT Southwestern, USA. The Zhang lab broadly focuses on genetic and epigenetic regulation of glial cells (astrocytes, NG2 glia, and microglia) under pathological conditions including neural injuries (spinal cord injury, brain injury) and neurodegeneration (Alzheimer’s, Parkinson’s diseases, amyotrophic lateral sclerosis). In vivo cell fate reprogramming for neurogenesis and regeneration will also be examined. Our projects will utilize multi-omics, virus-mediated engineering, lineage tracing, live cell imaging, neural circuit mapping, and animal behaviors.
The Zhang Lab is well equipped for both in vitro and in vivo studies in molecular, cellular, and behavioral neuroscience. Their studies are published in Cell, Cell Stem Cell, Nature Cell Biology, Nature Communications, PNAS, Cell Reports, Stem Cell Reports, etc. Their discoveries are extensively reported by the news media, such as reprogramming in the adult brain (The Scientist Magazine, Science Magazine), astrocyte reprogramming in the adult spinal cord (The Scientist Magazine, Neurology Today), reprogramming NG2 glia for regeneration and recovery after spinal cord injury (Fiercebiotech, Eurekalert), modeling human amyotrophic lateral sclerosis (ALS) with adult-converted motor neurons (Alzforum, ALS News Today), and in vivo reprogramming of mature neurons (Discover Magazine, Science Magazine).
Selected Recent Publications (since 2020)
Zhang et al., A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum. Proc Natl Acad Sci U S A. 2022
Wang et al., Revisiting astrocyte to neuron conversion with lineage tracing in vivo. Cell. 2021
Yu et al., NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis. Glia. 2021
Tai et al. In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury. Cell Stem Cell. 2021
Ding et al., Disease modeling with human neurons reveals LMNB1 dysregulation underlying DYT1 dystonia. J Neurosci. 2021
Ma et al., Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease. Mol Neurodegener. 2020
Yang et al., SOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cells. Proc Natl Acad Sci U S A. 2020
Candidates must hold a Ph.D. and/or M.D. degree, with strong publications in peer-reviewed journals. Previous experience in molecular biology, developmental biology, or neuroscience is strongly preferred. The successful candidate will also benefit from exceptional core facilities and a very collaborative environment. Information on our postdoctoral training program and benefits can be found in our Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.
Interested individuals should send a CV, statement of interests, and a list of three references to
Tagged as: Life Sciences
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