Andrea Arrieche Suarez

PhD

PhD Student

cell based assays Cell Culture chemical biology Imaging Assays Medicinal Chemistry Organic chemistry Screening of chemical libraries against cancer. Structure-Activity Relationship Structure-Based Drug Design synergy studies

Peer-reviewed publication(s) Conference Poster(s) Patent(s)

Designed, synthetized and evaluated small molecule autophagy modulators for neurogenerative diseases. Also studied their mechanism of action using a variety of chemical biology techniques such as probe development, imaging assays, enzymatic digestion assays, co-immunoprecipitation and protein expression assays. I measured the effects of the hit compound on ER stress and protein degradation through the ubiquitin proteasome system and autophagy using patient derived fibroblast. Optimized synthetic routes to generate gram-scale quantities of lead compounds for in vivo studies

Designed, synthetized and evaluated small molecule autophagy modulators for cancer. Designed and optimized efficient synthetic routes to access hit compounds and a wide variety of analogues and performed structure-activity relationships studies to optimize potency, selectivity, metabolic stability, and chemical properties of autophagy modulators. I also studied the compound synergy in ovarian cancer cell lines as single agent as well as in combination therapy

I performed studies to determine the relationship between structure and cytotoxicity of previously developed autophagy modulators and analogues. I evaluated the effects of hit compound and selected analogues on apoptosis, necrosis, and autophagy-dependent cell death. I am currently focused on investigating the effects on these compounds on nucleophagy, a selective form of autophagy that targets nuclear proteins for degradation to preserve nuclear integrity