Associate Scientist – Analytical & Bioanalytical Mass Spectrometry (ABMS) Full-time

Associate Scientist

Regeneron Pharmaceutical's Analytical and Biological Mass Spectrometry Group (ABMS), located in Tarrytown, NY is seeking a motivated Associate Scientist to join our fast-paced and interdisciplinary team working on analytical and bioanalytical development on novel siRNA/oligonucleotide-based modalities in a diverse genetic medicine pipeline.

A Typical Day in the Role Might Look Like:

• Develop and optimize liquid chromatography coupled to mass spectrometry (LC-MS) related methods for the enrichment, detection, quantification, and structural characterization of siRNAs, oligonucleotides, novel siRNA conjugates and monoclonal antibodies (mAbs)
• Perform analytical testing and sample preparation of siRNA/oligonucleotides with a focus on chromatographic fractionation, LC, LC-MS, solid phase extraction (SPE), hybridization-capture, and other mass spectrometry related methods
• Independently conduct sample preparation and LC-MS analyses in compliance with SOPs or drafted protocols, and document experimental procedures and results in electronic laboratory notebook (ELN)

This Role May Be For You If:

• You are mentally flexible and adapt quickly to changing priorities in a fast-paced environment.
• You are an excellent team player who can follow directions while also bringing your own insights to problem-solving.
• You have a growth mindset and eagerly embrace new challenges and learning opportunities.
• You are interested in learning about genetic medicines and development for impactful RNA-based therapies.

This role requires a BS or MS degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field with 0–3 years of relevant hands-on laboratory experience in analytical chemistry or bioanalytical sciences. Strong hands-on experience with liquid chromatography (such as reversed-phase, size-exclusion, ion exchange chromatography) is essential, particularly HPLC or UPLC techniques. Hands-on experience with various types of biological matrices is a plus. Hands-on experience with fractionation, solid phase extraction and/or hybridization techniques would be particularly valuable.

While mass spectrometry experience is beneficial, we prioritize candidates with excellent chromatography skills and the ability to optimize separation methods. You should be comfortable working independently after initial guidance and be able to communicate effectively about technical challenges and results.