Doctoral student in laboratory medicine Full-time

Doctoral Student In Laboratory Medicine

Lund University, Faculty of Medicine, Dep of Laboratory Medicine, Lund

Lund University was founded in 1666 and is repeatedly ranked among the world's top universities. The University has around 46,000 students and 8,500 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

The Experimental Oncology research group at the Division of Translational Cancer Research, Lund University, led by Professor Kristian Pietras, is driven by the conviction that a tumor is a communicating organ consisting of several cell types that jointly develop into the deadly disease cancer. Tumors are heterogeneous and contain malignant cells with different proliferative and metastatic potential. While it is a well-established fact that the tumor microenvironment strongly contributes to a tumor's growth and development, we do not know much about heterogeneity within cell types in the tumor stroma. Our strategy combines high-resolution studies of basic biological concepts with advanced mouse models of cancer and exclusive clinical patient data to investigate the role of the microenvironment in cancer initiation, progression and resistance to treatment.

Lund University is a public authority, which means that you will have special benefits, generous annual leave and an advantageous occupational pension. We also have a flexitime agreement that creates good conditions for work/life balance. Read more on the University's website about being a Lund University employee, Work at Lund University.

The transforming growth factor (TGF)-ß superfamily consists of more than 30 members that regulate cell fate, proliferation, growth arrest and apoptosis in various cell types. Our studies suggest that direct targeting of ALK1 is the most efficient means of exploiting TGF-ß signaling in stromal cells therapeutically. While ALK1 has historically been viewed as an endothelial cell-restricted receptor, our recent studies have identified its expression also in immuno-suppressive macrophages. Inhibition of ALK1 improves the efficacy of immunotherapy as a result of profound alterations in the immune cell landscape. Here, we will mechanistically explore the role for ALK1 at the crossroads of vascular biology and tumor immunity.

The requirements for the position are:

• M.Sc. in a relevant field, or equivalent
• Completed higher education courses in Oncology
• Experience from research in Oncology with resulting publications
• Experience from research with experimental animal models
• Experience from research employing mulitiplex immunohistochemistry

Additional qualifications for the position are:

• Completed MD education
• Experience from various educational research projects

Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Fixed-term employment for four years in accordance with Chapter 5, Section 7 of the Higher Education Ordinance (HF). The position is a doctoral studentship (PhD position), full-time (100%), with a start date of 1 September 2026 or according to agreement.

Applications must be submitted through the University's recruitment system. The application should include:

• A CV detailing qualifications and experience relevant to the position.
• A cover letter explaining the applicant's suitability and motivation for the position.
• Degree certificates.
• Contact details for two referees.

The Faculty of Medicine is a part of Lund University, and is responsible for education and research within medicine and healthcare. Our academic programs are closely linked with the healthcare system and are firmly anchored in the faculty's strong research tradition. Our research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malmö, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world.

The Department of Laboratory Medicine is one of six departments at Lund University's Faculty of Medicine. We conduct leading research, both broad and specialised, within the field of laboratory medicine, focusing on the onset of disease and how we can improve diagnostics and treatment for patients. Some of our strongest areas with world-class research deal with cancer, genetics and blood.