Physician Scientist, Therapeutic Area Genetics (Immunology) Full-time

Join Our Immunology Therapeutic Area Genetics Team

We are looking for an extremely talented Physician Scientist to join our Immunology Therapeutic Area Genetics (TAG) team. Within the Regeneron Genetics Center, the Immunology TAG team is using large-scale human exome sequencing for discovery and validation of new therapeutic targets in autoimmune and other immune-mediated disease. You will be responsible for designing and executing studies integrating large scale human genetics and multidimensional omics datasets derived from RGC and public resources in the immunology space to identify new targets for inflammatory and auto-immune diseases and accelerate target transition to novel therapeutics. You will collaborate with various RGC teams and with pre-clinical and clinical development teams at Regeneron to catalyze therapeutic development for genetically-validated targets in immunologic diseases.

Location: Tarrytown, NY

Discover Your Role

Understand and leverage RGC and Regeneron datasets, external resources, and the scientific/medical literature to generate research questions and then generate relevant phenotypes from longitudinal clinical data, design and execute genetic association studies, and perform integrative omics analyses to address these research questions

Deploy computational methods to integrate genetic data with multiple omics data to more effectively identify/prioritize drug targets illuminated by genetic association data.

Work closely with other members of the Immunology and other TAG teams, Analytic Genetics, Sequencing, and GIDE in cross-functional initiatives within the RGC and Regeneron.

Collaboratively summarize insights of investigations into a variety of formats (e.g. documents, presentations, patent applications, publications, etc.) for audiences with broad backgrounds.

Partner with Clinical Development to evaluate clinical stage programs and opportunities for human genetics studies to aid in the selection of indications or evaluation of safety considerations.

This Role Requires

MD or MD/PhD with a strong background in human genetics or genetic epidemiology

Experience in the use of WES/GWAS datasets, RNA-Seq, proteomics and other large-scale platforms for genomic/proteomics.

Demonstrated expertise in immunobiology, genetics, and mechanisms; familiarity with large genetic studies that deliver novel genetic findings and medically relevant gene discoveries;

Demonstrated ability to manage and collaborate in a multi-disciplinary team, to discover and evolve immunology-related drug discovery pipelines.

Individuals with proficiency in computational immunology research are particularly encouraged to apply.