PK/PD and QSP modeler, Neuroscience – Principal Scientist / Associate Scientist, DMPK & Modeling Full-time

PK/PD And QSP Modeler, Neuroscience – Principal Scientist / Associate Scientist

Takeda is unwavering in our commitment to patients. With the patient at the center of everything we do, we continue to innovate and drive changes that will better their lives. Takeda is a global industry leader –we are united by our four priorities (Patients, Trust, Reputation, and Business) and our shared values of Takeda-ism: Integrity, Fairness, Honesty, and Perseverance. Takeda-ism is more than just a word. It's a belief and a mindset which guides our decisions, behaviors, and interactions. It's how we strive to work and live, every day.

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a PK/PD and QSP modeler, Neuroscience – Principal Scientist / Associate Scientist in our Shonan, Kanagawa location.

As a PK/PD and QSP modeler, Neuroscience – Principal Scientist / Associate Scientist in DMPK & Modeling, you will be empowered to interface between biology/pharmacology, chemistry/biologics, nonclinical safety assessment, drug metabolism, translational medicine, clinical pharmacology and clinical research, to influence drug discovery and development.

Accountabilities:

• Drive decision-making in drug discovery and development by building a quantitative model of novel therapeutic agents to treat various neurological diseases including neurodegeneration and neuromuscular diseases.
• Work on cross-functional teams with preclinical biology/pharmacology, chemistry/biologics, nonclinical safety assessment, translational medicine, clinical pharmacology and clinical research to develop a quantitative model-based understanding of the interactions of target biological pathways and novel therapeutic agents, and their impact on disease progression.
• Formulate and implement team-engaged right modeling & simulation strategy. Design and build translational PK/PD/efficacy and mechanistic and/or systems models to assist and accelerate decisions around drug candidate selection, study design optimization as well as biomarker selection.
• Enable translational predictions of human pharmacologically active/efficacious dose, dosing schedule and safety margin for clinical trials. Leverage clinical benchmarking insights from clinical comparators and/or their reverse translation.

Education & Competencies:

• MS/PhD/PharmD in chemical or biomedical engineering, pharmaceutical sciences, mathematics, physics, or equivalent area.
• Strong competency in building mathematical models is required (in commonly used languages such as MATLAB, SimBiology, NONMEM, Monolix, Phoenix, Python, or R)
• Experience in mathematical modeling of biological systems. Especially, an experience and/or interest in applying modeling and simulation approaches to neurological diseases is preferred.
• Demonstrated strong analytical skills to evaluate complex information and identify key scientific questions.
• Ability to communicate complex modeling results clearly and concisely to cross-functional audience is critical.
• Good English communication skill in both written and verbal (TOEIC score ≥750, etc.) to work under global team setting

Takeda Compensation and Benefits Summary:

• Allowances: Commutation, Housing, Overtime Work etc.
• Salary Increase: Annually, Bonus Payment: Twice a year
• Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45
• Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)
• Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.
• Flexible Work Styles: Flextime, Telework
• Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.

Important Notice concerning working conditions:

• It is possible the job scope may change at the company's discretion.
• It is possible the department and workplace may change at the company's discretion.

Locations

Fujisawa, Japan

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time