Postdoc Research Scientist, Ion Mobility Mass Spectrometry (IM-MS) and Capillary Electrophoresis MS (CE-MS) (2 years) Full-time

Postdoc Research Scientist, Ion Mobility Mass Spectrometry (IM-MS) and Capillary Electrophoresis MS (CE-MS) (2 years)

Johnson & Johnson Innovative Medicine (J&J IM) develops treatments that improve the health of people worldwide. Research and development areas encompass cardiopulmonology, immunology, communicable diseases, neuroscience and oncology. Our goal is to help people live longer, healthier lives. To learn more about J&J Innovative Medicine, visit jnj.com.

The Translational ADME Biotransformation team in Beerse, Belgium, is looking for a highly motivated Postdoctoral Research Scientist (2 years contract) to lead and conduct experimental studies on conformational analysis of small and large molecules using ion mobility–mass spectrometry (IM-MS) and capillary electrophoresis-mass spectrometry (CE-MS). The candidate will design and execute experiments to probe conformational information, develop and optimize IM and CE separations, analyze complex datasets, and contribute to method development for structural and analytical applications.

We are a highly motivated team with state-of-the-art laboratories. The project will be part of broader interdisciplinary research, with close interaction and collaboration with scientists across multiple areas of expertise.

Key Responsibilities

• Design and execute experiments using IM-MS and CE-MS for small molecules (metabolites, lipids) and larger molecules (peptides, PROTACs).
• Optimize ionization conditions, CE separations, and IM parameters to resolve conformers and isobaric species.
• Maximize the output from raw data using appropriate software and statistical analysis tools.
• Develop and implement data-processing pipelines (scripting and/or software tools) for Collision Cross Section (CCS) extraction, peak deconvolution, and statistical analyses.
• Collaborate within multidisciplinary teams to contextualize data within broader research objectives, propose and develop follow-up experiments, and document and present findings.
• Stay updated on advancements in mass spectrometry and related technologies. Implement new technologies and methods to enhance sensitivity, data quality and throughput.

Qualifications

• PhD in Analytical or Medicinal Chemistry, Pharmaceutical Sciences, Biochemistry, or a related field
• Very strong organic chemistry background and a solid understanding of molecular structure
• Strong hands-on experience with ion mobility-high-resolution mass spectrometry
• Demonstrated knowledge of gas-phase ion behavior, conformational analysis, and CCS concepts.
• Proficiency in data analysis software and ability to interpret complex datasets
• Practical experience with capillary electrophoresis coupled to mass spectrometry or equivalent front-end separations is an asset.
• Strong track record of scientific contributions (peer reviewed publications, patents, or presentations at major meetings) is a plus
• Proficiency in data analysis and scripting (Python, R, MATLAB, or similar) to process large MS/IM datasets is an asset
• Good understanding of NMR data analysis and interpretation
• Strong problem-solving skills, attention to detail, and ability to work independently and in teams.
• High level of flexibility, creativity and sense of responsibility
• Team player with strong interpersonal skills in an international team setting
• Strong communication skills in English, both written and verbal

What We Offer:

• Competitive salary and benefits package
• Opportunities for professional development in an exciting R&D environment
• Collaborative and inclusive work environment
• Access to state-of-the-art technology and resources

The anticipated base pay range for this position is: €60,000.00 – €96,255.00