Postdoctoral Research Associate – Pathology & Immunology Full-time

Postdoctoral Position Available

A postdoctoral position (Ph.D. or M.D./Ph.D.) is available in the laboratory of Dr. Sadaf Amin at WashU Medicine in St. Louis to investigate innate immune pathways in neurodegenerative diseases and brain aging.

The Amin Lab studies the role of neuro-immune interactions in the pathogenesis of neurodegeneration and age-related brain disorders. We are an enthusiastic and collaborative team seeking a highly motivated individual to join our new and growing research group.

Projects are available to (1) study immune–RNA crosstalk in neurodegeneration to decipher the role of maladaptive innate immune pathways in neuronal stress and death, and (2) examine how mito-nuclear retrograde signaling contributes to microglial dysfunction and senescence in Alzheimer's disease and related dementias. We use a combination of iPSC-based systems and transgenic mouse models coupled with novel approaches including single-cell sequencing, CRISPR–Cas9 screening, and interactome profiling. The work will contribute to our overall goal of advancing novel therapeutic targets for neurodegenerative disease.

Candidates with backgrounds in computational biology, stem cell biology, or neuroscience are strongly encouraged to apply.

Primary duties and responsibilities include:

• Assists with grant preparation and reporting.
• Prepares and submits papers on research.
• Assists in the design of research experiments.
• Evaluates research findings and assists in the reporting of the results.
• Conscientious discharge of their research responsibilities.
• Maintains conformity with ethical standards in research.
• Maintains compliance with good laboratory practice including the maintenance of adequate research records.
• Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
• Collegial conduct towards co-trainees, staff members and members of the research group.
• Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.

Working conditions include a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary range is base pay commensurate with experience.

Interested candidates should submit a cover letter, CV, and 3 letters of recommendation to Sadaf Amin at amins@wustl.edu.