Postdoctoral Research Associate – Pathology & Immunology Full-time NEW

Postdoctoral Position in Neuroimmunology

A postdoctoral position is available in the laboratory of Dr. Laura Campisi in the Department of Pathology and Immunology at Washington University in St. Louis. Our laboratory studies how T cells interact with the central nervous system (CNS) in amyotrophic lateral sclerosis (ALS), using both mouse models and human samples. We aim to uncover the fundamental immunology of how T cells are activated and maintained in the CNS during disease, and to determine whether these discoveries can be translated into new therapeutic targets. To address these questions, we combine fundamental immunology approaches, including high-dimensional multiplex spectral flow cytometry, with imaging and computational analyses. The successful candidate will lead an independent project within this program in a supportive, mentored training environment.

Washington University offers a highly collaborative and interactive research environment. Our lab is part of the Division of Immunobiology and is also affiliated with, and actively collaborates with, the Center for Brain Immunology and Glia (BIG), the Hope Center for Neurological Disorders, and the WashU Medicine ALS Center. These connections give trainees access to a vibrant neuroimmunology community, shared expertise and core facilities, and direct links between basic research and clinical ALS care. The appointment is viewed as a training or transitional period preparatory to an academic, industrial, governmental, or other full-time research or teaching career.

Primary Duties & Responsibilities:

• Design, conduct, and lead research projects investigating how T cells are activated, maintained, and function within the CNS in mouse models of ALS.
• Design, optimize, acquire, and analyze high-parameter multiplex spectral flow cytometry panels on immune cells from the CNS and peripheral tissues.
• Use imaging approaches (e.g., immunofluorescence and confocal microscopy) to characterize T cell localization and interactions with CNS cells.
• Apply computational approaches to analyze high-dimensional cytometry, imaging, and related datasets.
• Maintain mouse colonies and perform in vivo procedures and tissue collection in compliance with institutional animal care (IACUC) guidelines.
• Contribute, as appropriate, to studies of human samples in compliance with institutional review board (IRB) and biosafety requirements.
• Identify and evaluate candidate immune pathways and therapeutic targets emerging from the lab's findings.
• Present research at lab meetings, institutional seminars, and national/international conferences.
• Apply for independent postdoctoral fellowships and career development awards with the support of the PI.
• Help train and mentor graduate students, technicians, and undergraduate researchers in the lab.

General Responsibilities:

• Assists with grant preparation and reporting.
• Prepares and submits papers on research.
• Assists in the design of research experiments.
• Evaluates research findings and assists in the reporting of the results.
• Conscientious discharge of their research responsibilities.
• Maintains conformity with ethical standards in research.
• Maintains compliance with good laboratory practice including the maintenance of adequate research records.
• Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
• Collegial conduct towards co-trainees, staff members and members of the research group.
• Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.

Working Conditions:

• Works in a laboratory environment with potential exposure to blood and chemical hazards.
• The position involves work with laboratory animals (mice) and may involve handling human biological specimens.

Salary Range:

Base pay is commensurate with experience.

Applicant Special Instructions:

Interested candidates should submit a cover letter describing their research experience, interests, and career goals, a CV, and 3 letters of recommendation.

Review of applications will begin immediately and continue until the position is filled.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications:

Education: Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree.

Certifications /Professional Licenses :

No specific certification/professional license is required for this position.

Work Experience:

No specific work experience is required for this position.

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

Preferred Qualifications:

• Research background in neuroimmunology, neuroscience, or immunology.
• Hands-on experience working with mice (e.g., handling, breeding, dissection, and tissue processing).
• Demonstrated ability to implement laboratory procedures, conduct research and record findings.
• Hands-on experience with flow cytometry.
• Track record of research productivity, including at least one first-author publication (published or submitted).
• Strong written and oral communication skills and the ability to work both independently and as part of a team.
• Strong motivation, curiosity, and commitment to understanding immune mechanisms of neurodegenerative disease.
• Experience with spectral flow cytometry, including panel design and high-dimensional analysis.
• Experience with tissue imaging (e.g., immunofluorescence, confocal microscopy) and image analysis.
• Familiarity with computational analysis tools (e.g., R, Python, FlowJo, OMIQ, or similar).
• Experience with mouse models of neurodegenerative or neuroinflammatory disease.
• Experience working with human samples.

Questions:

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation:

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening:

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement:

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO Statement:

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University's policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity or shared ancestry, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. As a federal contractor, the university maintains affirmative action programs to implement its equal employment opportunity policy for individuals with disabilities and protected veterans, in accordance with Section 503 of the Rehabilitation Act of 1973, as amended, and the Vietnam Era Veterans' Readjustment Assistance Act of 1974 (VEVRAA), as amended.