Postdoctoral Researcher in Molecular Immunology Full-time

Postdoctoral Researcher in Molecular Immunology

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. Our key words are multidisciplinary, bridging, national and international collaborations.

The research group of Dr Lisa Westerberg seeks a Postdoc (experimental) in the field of Immunology to study immunodeficiency diseases and lymphoma. The Westerberg lab has a long track record in deciphering molecular mechanism for development of severe immunodeficiency diseases in children.

Ongoing research in the Westerberg lab is focused on understanding the molecular mechanisms for development of immunodeficiency diseases with high incidence of lymphoma. The Westerberg lab uses a multidisciplinary and collaborative approach, working closely with research groups at KI, Karolinska University Hospital, Science for Life Laboratory (SciLifeLab), and with international research groups. Patient samples are obtained from national and international collaborators.

Your mission

As a Westerberg lab member, you will perform studies of immune cells from patient samples, patient derived cell lines, gene edited cell lines, and animal models to examine how lymphocytes are affected by monogenetic mutations. Knowledge in mutations that affect the cell cytoskeleton in the cytoplasm and in the nucleus is an advantage. Knowledge using in silcio structural modeling of patient mutations will also be of advantage. The project is focused on identifying molecular and cellular alterations of patients´ lymphocytes. We aim to recruit an independent and motivated person who can set up and maintain workflows by implementing or adapting existing methods of the Westerberg lab.

As a Postdoc you will be part of a multidisciplinary and collaborative research team active within the fields of immunodeficiency disease, lymphocyte biology, and lymphoma. The Westerberg lab investigates immunodeficiency diseases and lymphoma using state of the art immunological technology including molecular biology tools such as CRISPR/Cas and AAV gene editing to generate patient mutations, advanced flow cytometry and microscopy, Omics approaches, and usage of both patient samples and experimental models. These efforts aim to map key molecular events that contribute to the disease pathogenesis of immunodeficiencies and lymphoma and to drive the development of precision medicine.

Your profile

To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

In addition to the aforementioned requirements for the position :

• Large experience in working with human B and T cells
• Knowledge in advanced microscopy and flow cytometry
• Molecular modeling and docking
• Molecular biology skill sets

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Immunodeficiency Diseases – Lisa Westerberg Group | Karolinska Institutet

Department of Microbiology, Tumor and Cell Biology | Karolinska Institutet

Application

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.