Postdoctoral Scholar Safety Pharmacology Part-time

Postdoctoral Scholar Safety Pharmacology

We are searching for the best talent for Postdoctoral Scholar Safety Pharmacology to be in Beerse.

Purpose:

We are seeking a highly motivated postdoctoral scientist for a two-year fixed-term position within the Global Safety Pharmacology team in Beerse, Belgium. The successful candidate will focus on developing a human-relevant in vitro CNS safety platform to support drug discovery and development programs.

You will be responsible for :

• The candidate will apply their neuroscience expertise to establish a 2D human co-culture system using hiPSC-derived glutamatergic neurons and glial cells. The functional robustness of this system will be assessed using high-density CMOS-based multi-electrode array (MEA) technology.
• In collaboration with cross-functional teams, advanced imaging approaches (e.g., high-content imaging) will be applied to characterize cellular morphology as well as molecular and network-level features within the co-culture system. Safety signature profiles will be integrated with off-target profiling and transcriptomics data to elucidate mechanisms underlying electrophysiological and morphological phenotypes.
• The role requires strong collaboration, adherence to ethical research practices aligned with the 3Rs principles, and excellent communication skills to support scientific publication and presentation of findings.

Qualifications / Requirements:

• PhD in Neuroscience, Physiology, Cell Biology, or a related discipline focused on CNS pharmacology or toxicity
• In-depth knowledge of molecular and electrophysiological mechanisms of drug-induced CNS effects, with a strong publication record
• Hands-on experience with relevant experimental techniques, such as
• hiPSC-derived neuronal and glial cultures (various methods and cell types; mono- and co-culture)
• Rodent primary neuronal cultures
• Multi-electrode array (MEA) recordings (CMOS-based high-density and passive systems)
• Imaging and molecular analyses (e.g., high-content imaging, RT-qPCR, transcriptomics)
• Familiarity with off-target profiling approaches
• Experience in developing high-throughput screening assays is an additional asset
• Strong analytical skills with the ability to interpret complex datasets using tools such as Excel, GraphPad, Spotfire, or similar platforms
• Excellent presentation and communication skills, with the ability to collaborate effectively in cross-functional teams
• Ability to independently plan, prioritize, and manage multiple tasks
• Commitment to ethical drug development aligned with the 3Rs principles
• Proactive mindset with the ability to stay current with emerging scientific advancements and adapt to evolving technologies
• Demonstrated ability to write scientific manuscripts
• Proficiency in English

Required Skills:

Preferred Skills:

The anticipated base pay range for this position is:

€60,000.00 – €96,255.00

Benefits:

In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees' and companies' performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees – and in some location's eligible dependents – can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.