Research assistant in new treatment development for Alzheimer disease Full-time

Research Assistant in New Treatment Development for Alzheimer Disease

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

Do you want to contribute to top quality medical research?

The project is integrated into the research group of Lars Tjernberg, which focuses on investigating disease mechanisms in Alzheimer disease and developing novel therapeutic strategies. The group consists of senior researchers, postdoctoral researchers, and students and offers a methodologically broad, interprofessional, and supportive research environment. We have established an integrated research pipeline encompassing mechanistic studies, compound design and screening, in vitro verification, and evaluation in cellular and animal models. We aim to use these platforms to elucidate the degradation mechanisms of pathological proteins and leverage this knowledge for the development of protein-targeted degraders for Alzheimer's disease.

Your Mission

We are seeking a motivated Research Assistant to support ongoing in vitro experiments investigating Tau-targeted degraders for Alzheimer's disease and establishing high-throughput screening assays. Your main responsibilities will include:

• Brain dissection and primary neuronal culture
• Compound evaluation in cell models with tau pathology
• Establishment of high-throughput screening assay and verification
• Maintaining accurate experimental records, data analysis, and management
• Manuscript writing

This is a full-time (100%) fixed-term position for 5 months. This position offers the opportunity to contribute to an active research project and gain practical experience in new drug discovery and development in Alzheimer disease.

Your Profile

We are looking for a highly motivated candidate with a strong interest in research and the ability to collaborate and work effectively within a team.

Requirements for the position

• Master's degree in biomedicine, neuroscience, molecular biology, or a related life science discipline
• Practical laboratory experience, including primary neuron culture, western blot, plasmid construction and transfection, flow cytometry and immunofluorescence.
• Training in laboratory animal science according to FELASA guidelines (or equivalent training for handling experimental animals).
• Ability to work both independently and collaboratively in a research environment.
• Good communication skills in English

Merits for the position is also experience of

• Compound evaluation
• Drug delivery system
• Studies of protein-protein interactions

What Do We Offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Solna

Choose to work at KI – Ten reasons why

The Department of Neurobiology, Care Sciences and Society (NVS) conducts world leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 540 employees and a revenue 2025 of 580 million SEK. It comprises seven divisions, located at Campus Flemingsberg and Campus Solna.

The Division of Neurogeriatrics consists of about 65 employees. The division conducts experimental and translational research related primarily to Alzheimer's disease and other neurodegenerative diseases, but also more general molecular mechanisms with biomedical relevance are studied. The division is mainly located in BioClinicum, KI Campus Solna, and partially in Neo, KI Campus Flemingsberg.