Research Fellow Full-time

Research Fellow

The purpose of this Postdoctoral Research Fellow position is to structurally characterize Protein Quality Control Pathways in neurodegeneration, focusing on ribosome translational defects. The role will leverage cutting-edge structural and cellular methods, specifically cryo-Electron Tomography (cryo-ET), to resolve the architecture, both in vitro at atomic resolution and in situ within the native cellular environment.

• To undertake experimental and computational work, under the supervision of Dr. Zhao. • Ph.D. in Biochemistry or Structural Biology (required). • Experienced in molecular cloning, protein expression, and purification for structural studies (required). • Prior experience with cryo-EM, cryo-ET data acquisition and processing, and cryo-FIB/SEM sample preparation (required). • Prior experience with structure modelling or structural mass spectrometry (desired).

• To maintain accurate records of data analysis protocols from raw data to completed analysis results. • To attend research team meetings. • To prepare reports and presentations of laboratory work for seminars, manuscripts for publication, public engagement initiatives and funding bodies. • To contribute to the induction and direction of other research staff and students as requested. It is expected that the post holder will support other members of the Division and collaborators in their research roles in addition to developing their own project. • To contribute to the overall activities of the research team and department as required, including teaching and supervision of undergraduate or post-graduate students. • To actively follow UCL policies on Health and Safety, Race Equality, Equal Opportunities, Research Governance and Research Ethics.

Enquiries: Contact at Dr. Dorothy Zhao at dorothy.zhao@ucl.ac.uk