Research Fellow (Postdoctoral) – School of Biosciences – 107374 – Grade 7 Full-time

Post-doc (Research Fellow) Positions in Integrative Structural Biology

Applications are welcomed from candidates in Europe and other overseas countries. Financial support for visa application fees is available, subject to eligibility and organizational policy.

There are Post-doc (Research Fellow) positions available in the field of integrative structural biology, based in the group of Prof. Teresa Carlomagno at the University of Birmingham. The research group studies the functional mechanisms of proteins, including intrinsically disordered proteins, nucleic acids and their complexes by integrative structural biology. The laboratory uses and develops high-field NMR spectroscopy methods as major structural biology tool, in combination with several other techniques. The Research Fellow will work in one of the following fields: RNA metabolism, regulation of gene expression, DNA repair, signalling. The post holder will use NMR spectroscopy, X-ray crystallography and/or Electron Microscopy, as well as Mass Spectrometry and Small Angle Scattering, to study the structure of protein–protein or protein–nucleic acids complexes and discover the mechanisms of their function and regulation. There are opportunities to develop new approaches to integrative structural biology with the combination of the techniques mentioned above. In addition, the Research Fellow will use molecular biology, biophysical and biochemical techniques to characterize biomolecular complexes and their activity in vitro and cellular biology approaches to verify the functional mechanisms in vivo.

Role Summary

• Operate within area of specialism
• Analyse and interpret research findings and results
• Work within specified research grants and projects and contribute to writing bids
• Contribute to public understanding of the discipline or similar.

Main Duties

The responsibilities may include some but not all of the responsibilities outlined below.

• Develop research objectives and proposals for own or joint research, in the area of interest of the hosting laboratory (Prof T Carlomagno)
• Acquire, analyse and interpret data – structural biology, biochemical and biophysical data
• Apply knowledge in a way which develops new intellectual understanding
• Disseminate research findings for publication, research seminars etc
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
• Contribute to writing bids for research funding
• Contribute to developing new models, techniques and methods
• Undertake management/administration arising from research
• Contribute to Departmental/Institute research-related activities and research-related administration
• Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader
• Collect research data; this may be through a variety of research methods, such as scientific experimentation and literature reviews
• Deal with problems that may affect the achievement of research objectives and deadlines
• Promotes equality and values diversity acting as a role model and fostering an inclusive working culture.

Person Specification

• PhD (or near to completion) in Biophysics/ Biochemistry/ Chemical Biology/ Structural Biology or related areas or equivalent qualifications
• Proficiency in either biomolecular NMR spectroscopy or single-particle electron microscopy, both in data acquisition and analysis
• Practical experience in a biochemical laboratory and/or handling nucleic acids
• High level analytical capability
• Ability to communicate complex information clearly
• Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
• Ability to assess resource requirements and use resources effectively
• Understanding of and ability to contribute to broader management/administration processes
• Contribute to the planning and organizing of the research programme and/or specific research project
• Co-ordinate own work with others to avoid conflict or duplication of effort
• Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly
• Willingness to work in a competitive, international environment

Informal enquiries to Teresa Carlomagno, email: t.carlomagno@bham.ac.uk