Researcher, Neuroscience Full-time

Researcher, Neuroscience

We are seeking an experienced and highly motivated Researcher to investigate the molecular mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Our research focuses on defining protein–protein interaction networks, elucidating disease-relevant molecular pathways, and understanding the cellular processes that contribute to neurodegeneration.

The successful candidate will play a key role in driving research programs, developing innovative proteomics strategies, and generating mechanistic insights into neurodegenerative disease biology. This position requires substantial expertise in neuroscience and proteomics, scientific independence, and the ability to lead complex experimental investigations from hypothesis development through data interpretation and validation.

Responsibilities will include developing and optimizing wide-ranging proteomics workflows; establishing robust experimental systems; and implementing orthogonal approaches to validate key findings. The candidate will be expected to develop experimental strategies, troubleshoot complex technical challenges, and continuously improve research methodologies to enhance data quality, reproducibility, and efficiency.

Additional responsibilities will include working with mammalian cell systems and disease-relevant cellular models, including iPSC-derived neurons where appropriate; performing biochemical, cellular, and imaging-based assays to investigate the functional consequences of disease-associated molecular interactions. The successful candidate will critically evaluate experimental results, integrate findings across multiple approaches, and collaborate with proteomics and computational experts to derive meaningful biological insights.

Beyond their individual research contributions, the Researcher will contribute to the scientific direction and strategic development of the neurodegeneration research program. They will take ownership of research projects, coordinate collaborative investigations, mentor junior researchers, and help establish new experimental capabilities. The candidate will also contribute to scientific publications, grant applications, research proposals, and presentations, and will be expected to communicate complex scientific findings clearly to interdisciplinary audiences.

Required Qualifications include a PhD and relevant postdoctoral research experience in neuroscience, neurobiology, proteomics, or a closely related discipline, with a demonstrated record of scientific independence. Strong expertise in proteomics and its application to biological research, substantial hands-on experience in molecular biology, biochemistry, and cell biology, demonstrated ability to independently conceptualize, design, and lead complex experimental studies, experience developing, optimizing, and implementing experimental workflows, experience managing multiple research projects, demonstrated ability to mentor junior researchers, and excellent written and verbal communication skills.

Preferred Qualifications include experience investigating neurodegenerative diseases, expertise in affinity purification–mass spectrometry, proximity labeling approaches, experience with CRISPR engineering, iPSC-derived neurons, neuronal cell culture, or other disease-relevant cellular models, and familiarity with quantitative proteomics, proteomic data analysis, structural biology, AI-driven approaches, computational or bioinformatics tools.

Please apply online with a CV, cover letter, and three references.

See Table 13B for the salary range for this position. A reasonable estimate for this position is $96,700-$257,100.