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PhD Student / Researcher / Scientist
PhD in Molecular & Celular & Genome Biology / Parasitology Full-time NEW
Job Description: The selected fellow will investigate how the SCF/CRL1 ubiquitin ligase regulates the DNA replication programme in Leishmania, within the context of a FAPESP Young Investigator Project. The work will involve the characterisation of SCF complex targets using genome engineering tools (CRISPR/Cas9 and DiCre), cell biology and biochemical approaches (microscopy, pulldown assays, ubiquitination assays and proteomics), as well as bioinformatics tools (MFA-seq and DNAscent) to define the functional impact of ubiquitination on genome replication.
Essentail Skills: Scientific motivation and availability to dedicate full-time to the project. Ability to read and interpret scientific literature in English. Completed undergraduate degree, or expected completion by the start of the fellowship, in Biological Sciences, Biomedicine, Biotechnology, Biochemistry, Pharmacy or related areas. Approval in the entrance examination for the Direct PhD programme linked to the Department of Biochemistry and Immunology at FMRP-USP. Compliance with the current FAPESP rules for the award of a Direct PhD fellowship.
Desirable Skills: Good communication skills, organisation and ability to work collaboratively. Although not mandatory, previous experience in molecular biology, work with Leishmania or other trypanosomatids, genome editing using CRISPR/Cas9 and DiCre, and microscopy will be considered an advantage. Basic knowledge of bioinformatics and sequencing data analysis will also be valued.
Monthly stipend: BRL 5,790.00, plus an annual research contingency allowance equivalent to 20% of the yearly stipend. The stipend is not taxable in Brazil.
How to apply: Applications must be sent to the indicated email address, with the subject line: “Direct PhD – Ubiquitination in Leishmania”. In the body of the e-mail, candidates should provide their full name and indicate two referees, including name, institutional affiliation and updated e-mail address. The following documents must be attached as PDF files: a motivation letter, maximum two A4 pages; complete academic transcript; and CV, maximum four A4 pages.
Application Deadline: 22 August 2026