Scientist Full-time

Join AstraZeneca's In Vivo Discovery Platforms Group

Join AstraZeneca's In Vivo Discovery Platforms group within the Biologics Engineering department, where we are pushing the boundaries of science to deliver life-changing medicines. Our passion for discovery drives us to explore novel therapeutic approaches across various diseases, including Oncology, Respiratory, Cardiovascular, and Infectious diseases. As part of our collaborative network, you will have the opportunity to engage with new and exciting technologies that are transforming patient care.

Accountabilities:

As a key member of the team, you will design and execute in vivo studies, interpret pharmacokinetic (PK) data, and develop and qualify PK assays to support discovery programs and novel platform technologies. You will evaluate panels of lead candidates in vivo, deliver high-quality PK datasets, and collaborate closely with cross-functional partners to inform data-driven decision making across programs. Your strong work ethic, exceptional organization, and clear communication will be critical to delivering impact and advancing our portfolio.

In This Role, You Will:

• Complete wet-lab experiments (80%) and data analysis (20%).
• Design and execute in vivo PK studies across relevant species; coordinate animal dosing, sampling, and logistics; ensure data integrity and compliance with internal SOPs and applicable guidelines.
• Develop, qualify, and, where required, validate PK bioanalytical assays fit for purpose across discovery and regulated contexts.
• Perform PK sample analysis, troubleshoot assays, and deliver high-quality datasets within agreed timelines; ensure appropriate controls and documentation for traceability.
• Collaborate with in vitro, in vivo, and bioanalysis scientists to build research plans and align on study designs; present data and recommendations to project teams and department leadership.
• Identify opportunities to streamline workflows, implement best practices, and adopt new technologies to improve throughput, quality, and decision speed.
• Assist with cell culture, including routine maintenance and expansion.
• Work within a matrixed environment across multiple groups.

Essential Skills/Experience:

Educational requirements: BS (5+ years) or MS (2+ years) with hands-on experience in animal handling, bioanalysis, pharmaceutical sciences, or a closely related discipline.

Required Skills:

• Strong background in immunochemical and/or cell-based assays, including experience with cell culture techniques, high throughput flow cytometry, ligand-binding, ELISA, MSD as well as other novel bioanalytical techniques and platforms.
• In-Vivo PK Expertise: Hands-on experience planning and executing PK in vivo studies, including animal dosing, sampling, and PK sample handling; understanding of species selection, exposure targets, and PK principles.
• Bioanalytical Skills: Practical experience with PK assay development and qualification (e.g., ligand-binding assays such as ELISA/ECL); familiarity with regulated bioanalysis expectations.
• Data and Tools: Proficiency with PK data processing.
• Communication and Collaboration: Strong written and verbal communication skills; demonstrated ability to present PK/bioanalytical results to multidisciplinary teams.
• Organization and Execution: Proven ability to manage multiple studies in parallel, meet timelines, and maintain meticulous documentation in accordance with SOPs and quality standards.

Desirable Skills/Experience:

• Laboratory experience with GxP regulations, documentation, regulatory guidance, and regulatory submission.
• Understanding of immunogenicity assessments and their impact on PK; experience with biologics modalities (e.g., mAbs, bispecifics, ADCs, peptides, nucleic acid-based therapies).
• Familiarity with spreadsheet, word processing, and graphical computer programs (e.g. Excel, Word, GraphPad Prism, etc.) and experience with electronic notebook keeping and data entry using Genedata Biologics.

AstraZeneca is where bold thinking meets relentless curiosity. Our ambition to transform outcomes across oncology, respiratory and immunology (R&I), cardiovascular, renal and metabolism (CVRM), and infectious disease drives us to harness advanced science and technology. With high-quality molecules across multiple indications and every stage of development, we make decisive, patient-first choices that accelerate impact. Our collaborative ecosystem brings together diverse expertise to tackle some of the most challenging diseases. Here, you can build a fulfilling career focused on improving the lives of millions of patients worldwide.

Ready to shape what's next? Apply today to join our team.

The annual base pay (or hourly rate of compensation) for this position ranges from $92,252 to $138,378. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.