Scientist, ADME RLT Full-time

ADME Scientist

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Position Summary:

Reporting to the Advisor, ADME RLT, the ADME Scientist will contribute to the characterization of new candidate radioligands being developed as part of POINT's discovery pipeline. This role will support laboratory activities to profile the distribution, metabolism, and clearance of experimental pharmaceuticals being tested in vivo and in vitro. The ideal candidate will have experience with high-throughput sample preparation, GLP documentation, liquid chromatography, and mass spectrometry, as well as handling anatomical, biological, chemical, and radioactive materials. We are searching for a motivated and enthusiastic scientist who contributes positively to the collaborative culture of our cross-functional team.

Responsibilities:

• Prepare samples from mammalian cells, human and model animal tissues and excreta, chemicals, and radioisotopes.
• Keep an accurate, compliant, current record of our radioisotope inventory, and proactively distribute this information to relevant stakeholders.
• Sustain laboratory operations by stocking our consumables inventory.
• Maintain and calibrate scientific instruments, including chromatography systems and mass spectrometers, keeping maintenance and performance records.
• Operate liquid chromatography and mass spectrometry instrumentation.
• Convert raw scientific data into reports using standardized templates.
• Perform bioconjugation and bioconjugate characterization.
• Maintain a safe working environment for themselves and others through full compliance with health and safety protocols and regulatory requirements governing the use of human tissue, hazardous chemicals, and radioactive materials.

Basic Requirements:

• Minimum B.Sc. in chemistry, biochemistry, chemical biology, pharmacy, or related discipline.
• Minimum 2 years relevant postgraduate experience in either academic or industry laboratory environment.

Additional Preferences:

• Experience with research and analysis of radioactive materials preferred; willingness to work with radioactive materials required.
• Experience performing instrumental analysis of biochemical/biological samples.
• Understanding of drug properties and in vivo behavior (PK/PD, ADME, and principles of medicinal chemistry).
• Working knowledge of MS Office.
• Experience and comfort working with open sources of ionizing radiation.
• Excellent problem-solving and decision-making skills.
• 1-2 years of experience in high-throughput sample preparation in industry is highly preferred.
• Technical training and experience using liquid chromatography, mass spectrometry, and related instrumentation.
• Competent in data processing, data analysis, critical thinking, and production of publication-quality visuals and writing.
• Prior experience with in vivo pharmacology is a strong asset.
• Knowledge or experience with radiopharmaceuticals and GLP/GMP protocols is an asset.
• Proficiency in virtual laboratory notebook software, such as Signals, and Benchling.

Additional Information:

The physical demands of this job are consistent with a lab environment.

• Work environment is onsite downtown Toronto near College Street and University Avenue at the MaRS building.
• Anticipate travel for team and client meetings. Traveling across borders may be required, proper travel documentation such as a valid passport and travel visas are required.
• Wearing standard PPE in the lab is required.
• Must have use of full dexterity to perform routine tissue culture, benchwork, etc. in a laboratory setting.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $78,750 – $157,300.

Full-time equivalent employees may also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a pension plan; vacation benefits; eligibility for healthcare benefits; flexible benefits (if applicable) life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.