Scientist I, Formulation and Process Development Full-time

Scientist I

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience – and products and services in our Allergan Aesthetics portfolio.

We are currently hiring a highly motivated Scientist I to join our tLNP drug product formulation and process development team. In this role, you will directly work on formulation and process development of the most exciting tLNP drug product, to support emerging research pipelines.

This position will report into the Principal Scientist and based at our San Diego office. This role will involve hands-on laboratory work. All duties will be performed in compliance with AbbVie's standard operating procedures (SOPs).

Experience with lipid nanoparticle formulation and purification processes, or experience with process development, engineering and manufacturing of biologics drug product processes are highly desired.

Responsibilities & Duties:

• Develop novel formulation, conjugation and purification process for lipid nanoparticles based nucleic acid formulations with targeting modalities.
• Prepare, formulate, and characterize nucleic based complex lipid nanoparticle formulations.
• Design, execute, and analyze DOE-based experiments to develop and optimize novel LNP formulations and lyophilized product development.
• Perform investigations of aberrant results, determination of root causes, and recommend action plan to ensure process robustness.
• Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs) and other manufacturing related documentation.
• Prepare technical reports and presentations which summarize procedures, study results, and data interpretation as needed.
• Works in cross-functional teams to deliver results in an accurate and time sensitive manner.

Qualifications:

• Bachelor's Degree or equivalent education with typically 5 years of experience, or Master's Degree or equivalent education with typically two years of experience.
• Understanding of lipid-based delivery systems and formulation science principles.
• Hands-on experience working with nucleic acid and/or lipid nanoparticle-based formulations, complex/nanoparticle formulations, other biological formulation and lyophilization formulation development.
• Ability to work in a well-lit heated and/or air-conditioned indoor office and occasional laboratory setting with adequate ventilation. Light physical activity performing non-strenuous daily activities of a productive/technical nature. May require long periods of standing/sitting.
• Comfortable working in a highly innovative, changing, fast-paced environment with multi-task skills is required.
• Ability to work under pressure and tight deadlines. Has the discipline to stay focused and complete specific tasks
• Detail oriented with good organizational skills.
• A team player with excellent verbal and written communication skills.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.