Scientist II, ADC/AOC Conjugation Full-time

Job Title

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience – and products and services in our Allergan Aesthetics portfolio.

Key Responsibilities

• Synthesis, purification, and characterization of antibody drug conjugates (ADCs) and antibody oligonucleotide conjugates (AOCs) on mg to gram scale under minimal supervision.
• Development, optimization, and validation of conjugation protocols specifically for antibody oligonucleotide conjugates.
• Optimization and validation of formulation buffers for bioconjugates.
• Application and refinement of automated techniques for ADC/AOC synthesis and purification.
• Collaboration with cross-functional teams to advance ADC/AOC discovery programs from conceptualization to early development.

Qualifications

• Bachelor's Degree, or equivalent education, with typically 3 or more years' experience or Master's Degree or equivalent education (no additional experience).
• Experience in Organic, Bioorganic, Analytical Chemistry, Biochemistry, Molecular Biology, or related field
• Demonstrated hands-on expertise in laboratory-scale protein purification using Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed-mode chromatography, and/or affinity chromatography. Experience with GE AKTA FPLC and Unicorn software is preferred.
• Strong experience in the discovery, design, synthesis, and purification of antibody drug conjugates (ADCs) and antibody oligonucleotide conjugates (AOC), including familiarity with associated chemistries and analytical methods.
• Hands-on experience with relevant analytical techniques such as HIC-HPLC, SEC, IEX, RP-HPLC, LCMS and capillary electrophoresis techniques (e.g., CE-SDS, icIEF).
• Proven problem-solving skills, motivation, enthusiasm, attention to detail, and the ability to thrive in a fast-paced, cross-disciplinary team environment.
• Excellent written and oral communication skills, with a strong record of collaboration and innovation.

Preferred

• Previous experience with linker chemistry and payload conjugation strategies specific to oligonucleotide therapeutics.
• Experience troubleshooting or optimizing the stability and delivery of antibody-oligonucleotide conjugates.

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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Pay Range: $58656 – 110500 USD

Where We Work

Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.