Scientist, In Vivo Immunology Full-time

Scientist In Vivo Immunology

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

In the plan to create a new hub for vaccine discovery in Cambridge, we are building new laboratories that will be focused on the development of state-of-the-art methods that will be supporting deep product understanding, process and product development, as well as testing of pre-clinical and clinical samples for new vaccines.

The Scientist in the In Vivo Immunology team will support preclinical in vivo studies and will represent the project team in spearheading GSK's innovation of novel viral vaccines and platform programs. You will have the opportunity to support the in vivo efforts on multiple viral vaccine programs and platforms within GSK and with external partners in a collaborative and matrix team. You will help design and write in vivo study protocols, coordinate and initiate preclinical studies, conduct experiments and analyze experimental data pertaining to the understanding of cellular mediated immune responses and humoral immune responses from novel vaccine candidates, formulations, and platforms.

Key Responsibilities:

• As a preclinical in vivo study point of contact, you will work in a matrix team to support the identification of novel vaccine candidates and support platform development.
• Help design, plan, conduct, coordinate, monitor, and analyze in vivo studies for vaccine and platform programs.
• Schedule, manage and track the life cycle of in vivo studies.
• Conduct dosing, perform IVIS imaging, collect tissues; be trained and experienced in animal handling, sample collection, and surgical procedures.
• Ensure adherence to GSK and regulatory requirements for compliance with IACUC guidelines through writing and reviewing in vivo study protocols.
• Conduct complex flow cytometry, particularly in characterizing immune responses for preclinical immunogenicity or challenge studies.
• Develop new flow cytometry panels and troubleshoot experiments.
• Analyze experimental data and document them in detail using an electronic notebook
• Prepare and document study protocols and final study reports as an author.
• Contribute to technical sections of patent applications, IND submissions, and scientific publications.
• Present study plans and results at project meetings.
• Develop new experimental techniques based on project needs.

Basic Qualifications:

• Ph.D., M.S., or B.S. degree in immunology or a related field. The required post-graduate work experience is 0 years for a Ph.D., 4+ years for an M.S., and 8+ years for a B.S.
• Experience in conducting in vivo animal studies within the fields of vaccines, infectious diseases, or immunology.

Preferred Qualifications:

• PhD with experience in viral immunology or infectious disease
• Experience with in vivo viral challenge models
• Experience working with multiple species
• Strong experience with immune-response related readout methods such as ELISA, Flow, Luminex, or qPCR methodologies.
• Deep understanding of immunology.
• Worked in a matrix team.
• A collaborative team player with strong interpersonal skills to work with various groups within the organization.
• Detail-oriented with the agility to balance multiple projects with short timelines.
• Experience in documentation of study protocols and reports.
• Excellent communication and writing skills.