Scientist l – LBA (Ligand Binding Assay) Ops Full-time

Job Title

Ligand Binding Assay Scientist (Scientist I)

Job Description

We are seeking an independent, knowledgeable, and highly motivated Ligand Binding Assay Scientist (Scientist I) to join the Quantitative Translational and ADME Sciences (QTAS) department at Abbvie Bioresearch Center in Worcester, MA.

The LBA Operations Bioanalytical team at ABC QTAS conducts non-regulated, pre-clinical quantitative bioanalysis assays of large molecule therapeutics like monoclonal antibodies (mAb), multi-specific Abs, antibody-drug conjugates (ADC), antibody oligonucleotide conjugates (AOCs), and fusion proteins for Pharmacokinetic (PK), Pharmacodynamic (PD) and Toxicokinetic (TK) studies using ligand binding assays to support early development and drug discovery efforts.

As a Scientist I, you will be responsible for: 1) Conducting pre-clinical sample analysis using ligand binding assays (MSD, ELISA) manually and using automated liquid handlers 2) Updating sample, protocol, and reagent management systems using electronic tools such as Laboratory Information Management System (rLIMS) and e-notebooks 3) Reporting, discussing, and QC'ing results to project teams which enable pharmacokinetic and pharmacodynamic analysis in support of oncology, immunology, neurology, and other AbbVie therapeutic portfolios.

The ideal candidate will be a self-motivated, highly adaptable scientist with strong attention to details, has the ability to quickly learn new concepts, and a commitment to clear, consistent communication in a fast-paced, dynamic environment.

Duties & Responsibilities

• Analyze samples by ligand binding assays (PK, PD, TK, ADA) using Meso Scale Discovery platform and colorimetric ELISA or other assay platforms.
• Plan and execute sample analysis based on bioanalytical protocols and in vivo study designs on a variety of biological matrices (tissue lysates, serum, others) from a variety of species (monkey, mouse, rat).
• Analyze pre-clinical in vivo samples based on a dynamically changing operational schedule.
• Interpret, present, and discuss assay results; use results to guide analysis and adjust strategy.
• Perform timely, accurate, and thorough data archiving in ELN and rLIMS.
• Communicate experimental plans and results effectively, both verbally and in writing during regular lab meetings and with broader teams
• Actively support day-to-day laboratory operations.
• Write and update experimental protocols and procedures.
• Independently and efficiently initiate, design, interpret, and troubleshoot operational assays.

Qualifications

• Bachelor's degree in biology, biochemistry, pharmacology, or related field with at least 5 years of pharmaceutical experience or MS in mentioned fields with 2+ years of relevant experience.
• Experience with ligand binding workflow and assay development and troubleshooting is required.
• Strong attention to detail, with demonstrated impact as an independent and self-motivated contributor.
• Ability to operate and maintain laboratory equipment and reagents/material inventories independently.
• Experience with lab automation is desirable.
• Proven independence and problem-solving ability.
• Excellent written and verbal communication skills and ability to draft technical reports.
• Proficiency with computers and data analysis/documentation software including Excel, LIMS, and ELN.
• Ability to summarize, communicate, and interpret bioanalytical results.
• Ability and willingness to work effectively in a highly collaborative and multidisciplinary environment.

Additional Information

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only – to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

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Pay Range: $75000 – 142500 USD