Senior Associate Scientist – RGM Chemistry Full-time

Senior Associate Scientist

At Regeneron Genetic Medicines, we are driven by a mission to transform the treatment of serious diseases through groundbreaking genetic therapies. Our team is at the forefront of innovation, applying cutting-edge science to improve patient outcomes and redefine the future of medicine.

We are seeking a highly motivated and detail-oriented Senior Associate Scientist to join the RGM R&D Chemistry team with a focus on oligomer and oligonucleotide synthesis, purification, and analytical characterization. The successful candidate will support the design and execution of solid-phase synthesis workflows, contribute to the preparation of modified RNA-related materials, and generate high-quality analytical data to guide platform research and development. This role offers an opportunity to work at the interface of synthetic chemistry, analytical characterization, and RNA therapeutic innovation while contributing to programs that may meaningfully advance future medicines.

What You'll Do:

• Execute solid-phase oligomer and oligonucleotide synthesis using automated synthesis platforms, including preparation of reagents, setup of synthesis cycles, incorporation of standard and chemically modified amidites, and on-bead or post-synthetic modifications as needed.
• Support synthesis of RNA-related constructs of varied lengths, formats, and chemical modification to enable discovery, platform development, and cross-functional program needs.
• Develop, optimize, and troubleshoot synthetic workflows to improve yield, purity, reproducibility, and process efficiency.
• Perform purification of synthesized oligomers using appropriate chromatographic techniques, including size-exclusion, anion-exchange, reverse-phase, and ion-pair reverse-phase methods.
• Characterize purified materials using analytical methods such as LC-MS, HPLC/UPLC, UV-Vis, and other orthogonal techniques to confirm identity, purity, concentration, and product quality.
• Analyze and interpret experimental results, summarize findings clearly, and recommend next steps to support iterative chemistry design and platform advancement.
• Maintain accurate, complete, and timely experimental records in accordance with laboratory standards, safety expectations, and internal documentation practices.
• Support routine operation, maintenance, troubleshooting, and inventory management for key synthesis and analytical instrumentation, reagents, and laboratory supplies.
• Collaborate effectively with chemists, biologists, analytical scientists, and project teams to advance RGM Chemistry objectives and communicate technical progress in team discussions.

Let's Find Out If We're a Fit:

• B.S. in chemistry, biochemistry, chemical biology, biology, or a related scientific discipline is required; Masters degree is preferred
• Minimum of 5 years with BS / 3 years with MS in relevant undergraduate research, internship, or industry experience required.
• Hands-on experience with solid-phase organic synthesis is preferred, particularly oligonucleotide, peptide, oligomer, or related polymer/biopolymer synthesis workflows.
• Nice to have – familiarity with automated synthesis platforms such as MerMade, OligoSynt, or comparable oligonucleotide/oligomer synthesizers is highly desirable. Experience with purification and analytical characterization methods, including SEC, AEX, RP-HPLC or RPIP-HPLC, and LC-MS.