Senior Scientist – BioAnalytical Research Full-time

Job Opportunity at Lilly

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Bioanalytical Scientist Position

The Bioanalytical Research Group (BAR) in Investigative ADME/Toxicology and BioAnalytical Research at Louisville, CO is seeking a scientist skilled in small molecule mass spectrometry to deliver innovative ways in our evaluation of the ADME properties of radioligand therapeutics (RLTs). This role has an emphasis on bioanalysis of small molecule drug, with the possibility to expand to large molecule therapeutics, such as antibody-drug conjugate (ADC).

Primary Responsibilities

• Perform sample preparation (e.g. tissue homogenization, multiwave digestion) and operate mass spectrometer to develop bioanalytical methods and perform quantitative bioanalysis (bioA) of small molecule therapeutics from in-vitro and in-vivo samples.
• Investigate the structure-activity relationship (SAR) including pharmacokinetics (PK), biodistribution (bioD), biotransformation (BioT) and metabolite identification (metID) of drug molecules using LC-MS/MS.
• Collaborate with ADME project leaders to support fast-paced drug discovery projects. Serve as bioA representative and provide bioanalytical expertise to project team.
• Maintain and troubleshoot lab instruments to ensure their operation.

Job Requirements

• Bachelor's degree in Science or Engineering (Chemistry, Biochemistry, Chemical Engineering, Bioengineering or related field) with 3 years of work experience.
• Experience with using Inductively coupled plasma mass spectrometry (ICP-MS) in bioA method development, qualification and transfer for RLTs.
• Experience with small molecule bioanalysis in various matrices, including blood, tissue and excreta.
• Knowledge of drug ADME principles in understanding PK and biodistribution of small molecule therapeutics.
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role.

Preferred Qualifications

• Experience with discovery and development of radioligand therapeutics (RLT). Hands-on experience in sample preparation, LC-MS bioanalytical workflow of RLT in-vivo samples from Cold BioD and IV/PK studies. Experience of using ICP-MS (Agilent 8900) is a strong advantage.
• Experience in small molecule bioanalysis, from sample preparation, LC-MS operation, in-vitro or in-vivo metabolism.
• Familiar with MS-related informatic tools to conduct in-depth data analysis. Experience with AI-based data analysis and report writing.
• Previous experience in experiment documentation (eLN, signals, benchling, etc.), PK calculation (Phoenix, Watson LIMS, R-studio aNCA), data visualization (PRISM, BioRender) and report QC.
• Hands-on experience in automation or liquid handler instruments, such as Apricot, Hamilton, Tecan and KingFisher to support high-throughput bioanalytical assays.

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Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 – $213,400.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees.