(Senior) Scientist, Obesity Full-time

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The Position

Lead multidisciplinary drug discovery project teams from target identification through preclinical candidate selection. Proactively 'invent' future medicines by identifying high-value targets in the obesity and cardiometabolic diseases space.

Proven expertise in building disease-relevant cellular assays for metabolic disorders using immortalized and/or primary human and animal cells, including co-cultures and/or organoid culture systems

Capable in designand execution of in vivo studies to characterize the pharmacology of novel targets. Extensive familiarity with in vivo workflows, including experimental design, surgical/dosing techniques, and interpretation of metabolic phenotypic data. This includes evaluating regulation of body weight/composition, glucose and lipid utilization and total energy balance.

Partner with colleagues in molecular pharmacology, chemistry, and in vivo biology to perform biochemical and molecular assessments on ex vivo samples, ensuring an integral understanding of drug action.

Requirement for accurate record keeping, independent data analysis, and reporting of data in written and oral formats. Exceptional attention to details with excellent written and verbal communication skills to clearly articulate complex concepts at all levels of the organization.

Desired

Deep expertise in the biology of energy balance regulation and the pathophysiology of adipose tissue (white, brown, and beige fat).

Hands-on experience with functional metabolic assays, including insulin sensitivity and glucose/lipid metabolism, mitochondrial function and cellular respiration (e.g., Seahorse assays), assessment of body composition (e.g., EchoMRI or DEXA).

Specific experience studying the interplay between adipose tissue and neural biology (e.g., sympathetic innervation of fat or central control of metabolism) is a plus.

Qualifications

PhD and/or postdoctoral training with a focus on metabolism, physiology, biology or related field with well recognized peer-reviewed publications in metabolic research.

Proven experience leading drug discovery projects in metabolism discovery within a pharmaceutical or biotechnology setting is highly desired.

Roche is an Equal Opportunity Employer.