Senior Scientist in vitro ADME Full-time NEW

ADME Senior Scientist

At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

We are recruiting for an ADME senior scientist to join the DMPK&BBA department within Research and Early Development Cardiovascular, Renal and Metabolism (CVRM). You will strengthen our in-vitro ADME team and increase our capabilities regarding in-vitro ADME, across all drug modalities.

CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. CVRM DMPK is based in AstraZeneca's world-class vibrant R&D center, located in Gothenburg, Sweden. DMPK interacts with other functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management.

ADME (Absorption, Distribution, Metabolism and Elimination) scientists work with all aspects of drug disposition, stretching from tissue exposure to subcellular drug handling, and relating to drug effects. We are accountable for the breadth of the CVRM drug portfolio. This laboratory based scientific role delivers high-quality data and scientific insights aligned with project needs. The role requires effective communication to provide clear data and guidance to project representatives, oversee externalised studies, and contribute to DMPK scientific strategy. The position requires sound scientific judgement about DMPK information sets, innovative problem-solving and cross-functional collaboration.

Main Duties and Responsibilities

This is a laboratory based role and as a specialist in drug disposition, you will provide proficient scientific advice to project teams and deliver on project goals across all modalities in the portfolio while developing novel approaches.

Your key responsibilities include:

• Design, conduct, interpret and report in vitro ADME studies using established protocols and bespoke designs, applying state-of-the-art techniques, including e.g. 3D cell cultures, to support drug discovery and development. Additionally, you will provide oversight of outsourced studies and work with contract research organizations (CROs).
• Work independently on experimental design and analysis, while incorporating input from colleagues. You will identify and implement technology improvements to achieve scientific and business goals.
• Stay current with scientific advances, applying new knowledge to your projects and sharing insights with colleagues. You will suggest improvements in approaches, equipment, or techniques.
• Communicate data and guidance clearly to project teams, contributing to overall team delivery and planning all work to Good Laboratory Standards (GLS).
• Write manuscripts and publish research with internal and external collaborators, building your scientific profile.
• Participate in cross-functional workstreams, lead the development and implementation of DMPK scientific strategies, and contribute to DMPK scientific strategy discussions within AstraZeneca.

Essential Requirements

• A PhD, or MSc with relevant experience post graduation
• Background in Pharmacy, Biology, Biochemistry, Medical Biosciences or related subject area.
• Good knowledge of ADME processes and in-vitro models of drug disposition, with experience in development, characterization and application of translatable in-vitro models
• Broad laboratory proficiency in e.g. handling and culturing primary human hepatocytes and other human cells/tissues, molecular biology methods, image analysis, and enzyme / transporter kinetic studies
• Strong communication skills in English, both verbal and in writing
• Collaborative abilities and team-player to engage across boundaries with a problem-solving approach and focus on delivery.

Desirable Requirements

• Industry experience
• Expertise in bioanalytical techniques, e.g. LC-MS, qPCR, and PCR
• Experience with automation equipment and automated processing

At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

We welcome your application (CV and Cover Letter) no later than 16th August, 2026! Please expect communication after advert closing date.