Clinical Research Fellow Full-time

Clinical Research Fellow

We are seeking a Clinical Research Fellow to join an exciting MRC-funded experimental medicine programme investigating a newly identified link between TDP-43 pathology and the immune system.

The Fratta Lab has discovered that TDP-43-induced cryptic peptides act as neoantigens that drive a cytotoxic T-cell response in ALS and inclusion body myositis (IBM), and that low-dose IL-2 treatment -which was recently shown to modify disease progression in ALS in the Phase IIb MIROCALS trial (Lancet, 2025) -may act, at least in part, by dampening this response.

This is a unique chance to lead the patient-facing components of this programme, recruiting and following patients with ALS and IBM through an IL-2 experimental medicine challenge, while also playing a central role in data analysis and the scientific leadership of the project. You will work within a highly collaborative international team spanning UCL, King's College London, and the University of Pennsylvania.

The role is ideally suited to a neurology trainee seeking to develop deep expertise in translational research at the interface of neurodegeneration and immunology within one of the UK's leading clinical neuroscience environments. It may also be possible to enrol for a PhD; this should be discussed with Professor Fratta.

An honorary contract will be sought from UCLH NHS Foundation Trust, for which a DBS check will be required.

The role is available from 01 October 2026 and funded by the UK Medical Research Council (MRC) for 12 months in the first instance, with the possibility of extension to 36 months.