Senior Scientist I, Analytical Development – Mass Spectrometry tLNP CMC Full-time

Mass Spectrometry Scientist

The Analytical Development group within the Targeted LNP (tLNP) CMC Development Team at AbbVie is dedicated to advancing state-of-the-art analytical capabilities for tLNP therapeutics development. Our team provides critical support to tLNP drug substance, drug product, and formulation development. We leverage advanced biophysical, separation, and mass spectrometry techniques to deeply characterize antibodies, mRNA, lipids, and intact LNP particles. We are building a strong team of scientists who will be instrumental in developing and deploying the analytical toolbox needed to deliver high-quality, innovative tLNP medicines to patients.

As the mass spectrometry SME within the Analytical Development group of tLNP CMC Development team, you will work in an innovative analytical research and development lab and develop LC-MS method for characterizing biotherapeutic products to support tLNP development, with an emphasis on mRNA and oligonucleotide analysis. The successful candidate will have hands-on analytical method development experience of LC-MS analysis. Additionally, the candidate must foster productive collaborations within the global Analytical CMC organization and with R&D cross-functional partners such as Discovery, Process Chemistry, Process Engineering, Drug Product Development, and Quality Assurance and CMC-Regulatory Affairs.

Responsibilities:

• Operate, maintain, and troubleshoot mass spectrometry (Orbitrap, TOF) and liquid chromatography platforms, along with general laboratory equipment.
• Document instrument performance, organize regular maintenance, and coordinate with service engineers during maintenance and troubleshooting activities.
• Lead and execute characterization activities to evaluate and elucidate critical quality attributes of mRNA, such as 5' capping efficiency, 3' polyA tail distribution, and oligonucleotide sequence mapping.
• Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to solve drug development challenges.
• Proactively advance LC-MS characterization of biotherapeutics by developing innovative techniques that address evolving developmental needs and improve operational efficiency.
• Independently conduct sample preparation and LC-MS analyses in compliance with SOPs, and document experimental procedures and results in electronic laboratory notebook (ELN).
• Author and review regulatory submission documents, such as IND and comparability study.

Qualifications:

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field with 0-3 years of industry experience.
• Previous experience with mRNA, oligonucleotide, antibody, and LNP analysis by LC-MS is a strong plus.
• Experience in mRNA 5' capping and 3' polyA tail LC-MS analysis is preferred.
• Proficient in operating and maintaining mass spectrometry equipment, particularly LC-MS systems, and have experience in troubleshooting and maintaining LC-MS instruments, including tasks like changing and cleaning interfaces.
• Experience with LCMS data acquisition and analysis software, such as XCalibur, Protein Metrics, FreeStyle, Skyline, BioPharma Finder, and MassLynx.
• Organized, detail-oriented, and committed to maintaining proper documentation.
• Work independently while also collaborating effectively with a team of experts.
• Hands-on experience with additional analytical techniques relevant to mRNA or LNP analysis is a plus.
• Strong presentation and communication skills with the ability to explain data to technical and non-technical audiences.

Additional Information:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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Pay Range: $96500 – 183500 USD

Where We Work

Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.